Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) ELISA Kit (HUFI06160)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) hydrolyzes 3'-phosphotyrosyl linkages, resolving topoisomerase I-DNA cleavage complexes and 3'-phosphoglycolate ends during single-strand break repair. Quantifying TDP1 abundance in human specimens gives researchers a window into DNA damage processing, chemotherapeutic response, and inherited neurological syndromes linked to defective repair, including spinocerebellar ataxia with axonal neuropathy (SCAN1).

This ELISA kit from Assay Genie targets human TDP1 and is supplied as a 96 Assays plate format, supporting parallel analysis of clinical samples and experimental time-course studies. Each kit provides the reagents needed to generate a standard curve and quantify TDP1 levels in cleared biological matrices.

Applications include profiling TDP1 expression in tumor biopsies and matched controls, tracking induction of the repair pathway after exposure to camptothecin-class agents, and screening patient cohorts for variants associated with DNA repair deficiency. The workflow is straightforward for laboratories already running quantitative immunoassays, and the kit ships ready for direct use after equilibration of reagents to working temperature.