Human T-box transcription factor TBX21 (TBX21) ELISA Kit

Designed for the precise measurement of human T-box transcription factor TBX21 (also known as T-bet), this Sandwich ELISA Kit from Assay Genie is intended for research use only. TBX21 is a key T-cell-specific transcription factor that controls the expression of the TH1 cytokine interferon-gamma and initiates TH1 lineage development from naive TH precursor cells. Dysregulation of TBX21 has been linked to various autoimmune diseases and inflammatory disorders, making it a valuable biomarker for studying these conditions.

The kit is validated for use with human samples, including serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, and shows specificity for natural and recombinant human T-box transcription factor TBX21. Reported performance characteristics include a detection range of 0.156-10ng/mL, sensitivity of 0.098ng/mL, intra-assay CV of 6.1%, and inter-assay CV of 10.2%. Recovery is reported at an average of 114% for serum (range 108-120%) and 116% for plasma (range 110-120%). The associated UniProt accession is Q9UL17, with a molecular weight of 58,328 Da and nuclear subcellular localisation.