Human SUZ12 ELISA Kit (HUFI06246)

Suppressor of Zeste 12 (SUZ12) is a core scaffolding subunit of the Polycomb Repressive Complex 2 (PRC2), the multi-protein assembly that catalyzes trimethylation of histone H3 at lysine 27 and propagates repressive chromatin states at developmental loci and tumor-suppressor genes. Loss-of-function alterations and reduced SUZ12 expression have been reported in endometrial stromal sarcomas, malignant peripheral nerve sheath tumors, and a subset of other mesenchymal neoplasms, while elevated SUZ12 activity contributes to silencing of differentiation programs in stem cell and cancer models. Accurate quantification of SUZ12 protein abundance therefore supports epigenetics and oncology research workflows, from large cohort profiling to mechanistic cell-line studies.

The Human SUZ12 ELISA Kit from Assay Genie is an in vitro quantitative immunoassay built around a SUZ12-selective capture antibody and a chromogenic detection reagent for use with human serum or plasma-derived research specimens. Supplied as a complete microplate-based package sufficient for 96 individual determinations, the kit is intended for research use only. The protocol enables reproducible monitoring of Polycomb pathway status across patient cohorts, cultured cell-line models, and treatment-response studies, helping laboratories link SUZ12 protein levels to histone methylation readouts and downstream gene silencing phenotypes.