Human STUB1 (E3 ubiquitin-protein ligase CHIP) ELISA Kit  (HUES03512)

The STUB1 ELISA kit from Assay Genie provides quantitative measurement of human STUB1, the E3 ubiquitin-protein ligase also known as CHIP (C-terminus of Hsc70-interacting protein). STUB1/CHIP serves dual roles as a co-chaperone that binds Hsp70 and Hsp90 through its tetratricopeptide repeat domains and as a U-box E3 ligase that ubiquitinates misfolded substrates, targeting them for proteasomal degradation.

The protein is a central regulator of cellular proteostasis, with documented research relevance to neurodegeneration, cardiac stress response, cancer biology, and autosomal recessive spinocerebellar ataxia (SCAR16). Each kit contains reagents for 96 individual assay determinations, supporting biomarker studies, drug screening, and detailed pathway analyses. The workflow produces absorbance readings proportional to STUB1 concentration in experimental specimens.

Researchers apply this ELISA to investigate chaperone network dysregulation, aggregation-prone protein clearance, and heat shock response signaling across cell culture and in vivo model systems.