Human ST3GAL5 ELISA Kit (HUFI06309)

ST3GAL5, the Golgi-resident sialyltransferase responsible for initiating ganglioside biosynthesis, can be quantified in human research specimens using this colorimetric ELISA Kit from Assay Genie. The enzyme converts lactosylceramide to GM3, the precursor for most complex gangliosides in the central nervous system, and altered expression is associated with several neurodevelopmental and metabolic disorders.

Loss-of-function mutations in ST3GAL5 are linked to salt and pepper syndrome, an autosomal recessive condition characterized by early-onset epilepsy, developmental regression, and pigmentation abnormalities. Research applications include biomarker discovery in patient cohorts, enzymatic pathway characterization, and studies of glycosphingolipid metabolism in disease models.

Each kit provides reagents and standards for 96 individual determinations in a complete ready-to-use format. The plate-based protocol is compatible with standard microplate readers and supports workflows in neuroscience, glycobiology, and inherited metabolic disease research.