Human SMAD5 ELISA Kit (HUFI06447)

SMAD5 encodes a ~52 kDa protein that functions as a key intracellular signal transducer in the BMP/TGF-β superfamily signaling pathway. Upon BMP receptor activation, SMAD5 becomes phosphorylated and forms a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription of target genes involved in osteoblast differentiation, iron homeostasis, and hematopoietic stem cell maintenance.

Researchers employ quantitative SMAD5 measurement to investigate BMP-driven osteogenesis, study bone disease models, and explore signaling cross-talk in iron metabolism regulation. The Assay Genie kit supports research use only in laboratory workflows including cell culture supernatant and tissue lysate analysis.