Human Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1) CLIA Kit (HUES00555)

An immunoassay kit from Assay Genie is offered for the quantitative detection of human Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1). The kit uses chemiluminescence-based detection and is reactive with human samples, including serum, plasma, and other biological fluids.

The Mothers against decapentaplegic homolog 1 (SMAD1) protein functions as a transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase, acting as a receptor-regulated SMAD (R-SMAD). It is also referred to by synonyms including JV4-1, Mad-related protein 1, SMAD family member 1, BSP-1, MAD homolog 1, BSP1, MADH1, MADR1, and Transforming growth factor-beta-signaling protein 1, and is catalogued under UniProt entry Q15797 with NCBI Gene ID 4086.

SMAD1 mediates the signals of bone morphogenetic proteins, which are involved in cell growth, apoptosis, morphogenesis, development, and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase, and the phosphorylated form complexes with SMAD4 for transcription regulation.