Human SLURP1 (Secreted Ly-6/uPAR-related protein 1) ELISA KIT (HUFI04896)

SLURP1, the Secreted Ly-6/uPAR-related protein 1, is a small modulatory peptide of the Ly6/uPAR superfamily that influences nicotinic acetylcholine receptor signaling in epithelial tissues. The Assay Genie Human SLURP1 ELISA Kit provides laboratories with a quantitative assay to measure this protein in research samples, supporting investigations of skin barrier biology, keratinocyte differentiation, and cholinergic signaling at mucosal surfaces. Loss-of-function mutations in SLURP1 cause Mal de Meleda, a rare autosomal recessive palmoplantar keratoderma, and altered SLURP1 expression has been reported in lesional tissue from patients with psoriasis and atopic dermatitis, making it a relevant biomarker for dermatology research.

Configured as a 96-assay microplate kit for research use only, the assay includes a pre-coated plate, calibrated recombinant standard, biotinylated detection antibody, and substrate reagents needed to generate a standard curve and interpolate unknown sample concentrations. The protocol supports routine profiling in cell culture supernatants and tissue-derived preparations from human origin.

Investigators in dermatology, oral biology, and nicotinic receptor pharmacology will find this kit useful for studies of epithelial homeostasis and cutaneous inflammation. Detailed handling instructions and storage guidance are provided with the package insert to help ensure reproducibility between runs.