Human SIGIRR (Single Ig IL-1-related receptor) ELISA KIT (HUFI04875)

The Assay Genie human SIGIRR ELISA kit enables quantitative measurement of Single Ig IL-1-related receptor, also known as TIR8, a member of the interleukin-1 receptor superfamily that acts as a negative regulator of Toll-like receptor and IL-1 receptor signaling. SIGIRR is increasingly studied as a checkpoint molecule in innate immunity, with research relevance to mucosal inflammation, epithelial barrier function, sepsis biology, and chronic inflammatory disease pathways. The kit is configured as a 96-determination microplate assay run on standard laboratory equipment, producing absorbance-based readouts compatible with routine ELISA workflows and common benchtop plate readers. Each kit ships with all components required to complete the analytical protocol, including pre-coated plate wells, biotinylated detection antibody, standard calibrators, and the buffers and substrates needed to develop a full standard curve. Intended for in vitro research use only, this immunoassay supports academic, clinical, and translational laboratories investigating cytokine receptor biology, immune tolerance mechanisms, and the role of negative regulatory receptors in TLR and IL-1 signaling cascades. The assay targets human specimens and is supplied as a complete kit format sufficient for the full plate run.