Human SIGIRR PharmaGenie ELISA Kit (SBRS1089)

The Human SIGIRR PharmaGenie ELISA Kit from Assay Genie targets SIGIRR (Single Ig IL-1-Related Receptor), also known as IL-1R8 or TIR8, an atypical member of the interleukin-1 receptor superfamily that acts as a negative regulator of innate immune signalling through the IL-1R/TLR axis. Because SIGIRR dampens downstream responses from IL-1 family receptors and Toll-like receptors, quantifying circulating human SIGIRR supports research into chronic inflammation, sepsis, autoimmune disease, and tumour-microimmune interactions. The assay is species-specific for human SIGIRR and does not cross-react with the corresponding mouse or rat orthologues. Researchers in immune checkpoint biology and translational biomarker discovery use this kit to measure SIGIRR in cell culture supernatants, plasma, and serum samples, requiring 100 µL of sample per well in the supplied 96-assay microplate. Refrigerate on receipt, keep all reagents protected from light, and refer to the enclosed protocol for specific storage and handling of individual components.