Human SH3 Domain Binding Protein 2 (SH3BP2) ELISA Kit

The Assay Genie SH3BP2 ELISA Kit enables quantitative detection of SH3 Domain Binding Protein 2, an adapter molecule central to cytoplasmic signaling cascades that govern osteoclast multinucleation, B-cell activation, and macrophage inflammatory responses. Mutations in SH3BP2 are causally linked to cherubism, a rare craniofacial disorder characterized by excessive jawbone resorption, making this assay useful for studies in bone metabolism, dentistry, and immunology research. Each kit contains a pre-coated microplate, detection antibody, standards, and substrate solution; store the reconstituted components at -20 °C in single-use aliquots and avoid repeated freeze-thaw cycles. The microplate format allows processing of multiple samples in parallel within a standard ELISA workflow, and the procedure is intended for in vitro research use only. Researchers investigating the SYK / VAV / Rac1 axis downstream of SH3BP2 can pair this kit with cell culture supernatants or lysates from stimulated myeloid lineages.