Human SH2D2A ELISA Kit (HUFI06549)

Quantitative measurement of human SH2D2A, an SH2 domain-containing adapter protein also known as TSAd or VRAP, is supported by this immunoassay kit from Assay Genie. SH2D2A is encoded on chromosome 1p35 and acts as an intracellular signaling intermediate that links activated receptors to downstream effectors in T cells, including components such as Lck within the T-cell receptor signaling cascade.

Beyond its role in lymphocyte activation, SH2D2A participates in VEGFR2-associated vascular signaling, and altered expression has been examined in studies of multiple sclerosis susceptibility and other immune-mediated conditions. The adapter contains an SH2 domain together with proline-rich regions that mediate protein-protein interactions central to these pathways.

Built on the established ELISA principle, the kit provides reagents for 96 individual determinations in a standard microplate layout, accommodating routine immunology, cell-signaling, and autoimmunity research workflows. It is configured for use with human specimens and is intended for research use only, supplying the core components required to generate absorbance-based quantitative data on SH2D2A protein levels in experimental samples.

By targeting a specific adapter molecule at the intersection of T-cell activation, downstream kinase signaling, and vascular pathways, the kit enables laboratories to investigate mechanisms relevant to lymphocyte function, inflammation, and immune-related disease research.