Human SH2D1A ELISA Kit (HUFI06558)

SH2D1A encodes SAP (SLAM-associated protein), a small SH2-domain adaptor expressed predominantly in T lymphocytes and NK cells, where it mediates signaling through the SLAM family of receptors. The Assay Genie Human SH2D1A ELISA Kit is formatted as a complete immunoassay kit intended for research use only in the quantitative measurement of SH2D1A in human research samples.

Investigations supported by this kit include work on X-linked lymphoproliferative disease type 1 (XLP-1, also called Duncan disease), a primary immunodeficiency caused by loss-of-function mutations in SH2D1A, as well as studies of T-cell and NK-cell activation, immune synapse formation, and EBV-driven immune dysregulation. The reagent is supplied as a microplate-format research kit and applied in laboratory studies of immunology, cell signaling, and primary immunodeficiency research.