Human Serine/threonine-protein kinase SIK1 (SIK1) ELISA Kit

Manufactured by Assay Genie, this Sandwich ELISA kit enables quantitative measurement of human Serine/threonine-protein kinase SIK1 (SIK1), a key enzyme that regulates various cellular processes including gene expression, metabolism, and cell growth. The kit is reactive with human samples and accepts serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids.

The assay employs colorimetric detection with a reported detection range of 0.156-10 ng/mL and a sensitivity of 0.1 ng/mL. Precision is given as an intra-assay CV of 5.8% and an inter-assay CV of 9.3%. Recovery in serum averages 97% (range 91-103%), while in plasma it averages 99% (range 93-105%). Specificity is for natural and recombinant human SIK1, and the kit is intended for research use only.

Synonyms for SIK1 include Salt-inducible kinase 1, Serine/threonine-protein kinase SNF1-like kinase 1, SIK-1, Serine/threonine-protein kinase SNF1LK, SIK, and SNF1LK. The UniProt accession is P57059, and the protein is localised in the cytoplasm and nucleus. SIK1 acts as a tumor suppressor and has been implicated in several diseases, including cancer, diabetes, and inflammatory disorders, making it a relevant focus for cancer research.