Human Serine-protein kinase ATM (ATM) ELISA Kit

Manufactured by Assay Genie, this Sandwich ELISA Kit is intended for the quantitative detection of human Serine-protein kinase ATM in human serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay uses a colorimetric detection method and is specific for natural and recombinant human Serine-protein kinase ATM. Synonyms for the target include Ataxia telangiectasia mutated and A-T mutated.

ATM is a serine/threonine protein kinase that acts as a DNA damage sensor, activating checkpoint signalling upon double strand breaks and other genotoxic stresses. The manufacturer describes it as playing a key role in DNA damage response and repair, helping to maintain genomic stability. The reported detection range is 6.25-400 nmol/L with a sensitivity of 2.9 nmol/L, an intra-assay CV of 4.5% and an inter-assay CV of 7.8%.

Because mutations in the ATM gene have been associated with cancer and neurodegenerative disorders, the target is regarded as an important biomarker for disease research, with applications in cancer research. The product is for research use only. UniProt ID: Q13315.