Human Serine Peptidase Inhibitor Kazal Type 5 (SPINK5) ELISA Kit

Quantify LEKTI, the serine protease inhibitor encoded by SPINK5 on chromosome 5q31-q32, with this 96-assay kit from Assay Genie. SPINK5 (Serine Peptidase Inhibitor Kazal Type 5) is a 15-domain Kazal-type inhibitor that regulates kallikrein activity in epithelial tissues, controlling corneodesmosome shedding, hair shaft integrity, and mucosal inflammation. Loss-of-function mutations in SPINK5 cause Netherton syndrome, while altered expression is implicated in atopic dermatitis and asthma susceptibility research.

Validated for human tissue homogenates and cell lysates, the kit supports dermatology, immunology, and epithelial barrier studies. An absorbance-based microplate workflow allows straightforward data capture on standard plate readers, with results reported against a recombinant protein standard curve. Reagents are supplied in pre-measured vials; store components at 4°C between uses and minimize freeze-thaw cycles to preserve reagent activity. Intended for research use only, the format delivers 96 determinations per microplate kit.