Human SDHAF1 {ECO:0000303|PubMed:19465911, (Succinate dehydrogenase assembly factor 1, mitochondrial) ELISA KIT (HUFI04840)

SDHAF1 encodes a small mitochondrial protein essential for the proper assembly and stability of succinate dehydrogenase (complex II), where it facilitates insertion of iron-sulfur clusters into the SDHB subunit. Loss-of-function variants in SDHAF1 are linked to early-onset leukoencephalopathy with oxidative phosphorylation defects, making quantitative measurement of SDHAF1 valuable for studies of mitochondrial respiratory chain biogenesis, neurodegeneration research, and investigation of paraganglioma-predisposition pathways. The Assay Genie kit supports human sample-based profiling in clinical biofluids, providing a reproducible microplate immunoassay tool for laboratories working on mitochondrial disease biomarkers and metabolic dysfunction studies. Store kit components refrigerated at 4 degrees C and protect from light to preserve antibody binding activity across multiple freeze-thaw cycles.