Human SASH3 (SAM and SH3 domain-containing protein 3) ELISA KIT (HUFI08081)

The SASH3 protein functions as a signaling adapter in lymphocytes, where its tandem SAM and SH3 domains mediate protein-protein interactions downstream of T-cell receptor activation. Mutations in the SASH3 gene on the X chromosome have been linked to a recently characterized form of combined immunodeficiency with immune dysregulation, making accurate quantification of SASH3 levels valuable for immunology research, vaccine development studies, and investigations into autoimmune and lymphoproliferative disorders. Assay Genie supplies the reagents in a microplate configuration, including pre-coated plates, detection antibody, standards, and substrate. For best results, store the unopened kit refrigerated at 4 degrees C and protect components from light, avoiding repeated freeze-thaw cycles of the standard and detection antibody. The assay is intended for research use only and supports in vitro measurement of SASH3 in blood-derived specimens from human donors.