Human Ryanodine Receptor 1, Skeletal (RYR1) ELISA Kit

RYR1 encodes the ryanodine receptor isoform found predominantly in skeletal muscle, a homotetrameric intracellular calcium-release channel embedded in the sarcoplasmic reticulum membrane. Mutations in this gene are causally linked to malignant hyperthermia susceptibility, central core disease, and multi-minicore myopathy, making reliable quantification of the protein valuable for neuromuscular research and pharmacogenetic screening studies.

This Assay Genie ELISA is configured for use with human tissue homogenates and cell lysates, enabling direct measurement of RYR1 expression in muscle biopsy material and differentiated myogenic cultures. Researchers studying excitation-contraction coupling, calcium handling in exercise physiology, or drug-response profiling can pair the assay with western blot confirmation to validate findings.

The kit ships with all reagents required to perform 96 individual reactions on a microplate, including pre-coated wells, detection antibody, standards, and substrate. Store unopened components at 4 degrees C and protect from light; reconstituted working solutions should be aliquoted to limit freeze-thaw cycles. The kit is intended for research use only.