Human RuvB-like 1 (RUVBL1) ELISA Kit

Manufactured by Assay Genie for research use only, this sandwich ELISA kit is designed for the precise measurement of human RuvB-like 1 (RUVBL1) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. It targets natural and recombinant human RUVBL1 and is grouped under the epigenetics research area. Performance figures reported by the manufacturer include a detection range of 0.312–20ng/mL, a sensitivity of 0.12ng/mL, an intra-assay coefficient of variation of 6.3% and an inter-assay coefficient of variation of 9.7%. The associated UniProt accession is Q9Y265.

RUVBL1 participates in chromatin remodeling, DNA repair and transcription regulation, and its dysregulation has been associated with cancer, neurodevelopmental disorders and metabolic diseases, making it a valuable biomarker for studying these conditions and developing potential therapeutic interventions. The protein possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity, and may be able to bind plasminogen at the cell surface and enhance plasminogen activation.