Human Rho guanine nucleotide exchange factor 1 (ARHGEF1) ELISA Kit

From Assay Genie, this Sandwich ELISA kit is designed for the precise detection of human Rho guanine nucleotide exchange factor 1 (ARHGEF1) levels in human serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay has a sensitivity of 0.182ng/mL and a detection range of 0.312-20ng/mL, with an intra-assay CV of 8.1% and an inter-assay CV of 9.4%. It is specific for natural and recombinant human ARHGEF1 and is for research use only.

ARHGEF1 is a key protein involved in regulating cell signaling pathways and controlling cytoskeletal dynamics, and plays a role in cell migration, adhesion and proliferation. Dysregulation of ARHGEF1 has been associated with diseases such as cancer, cardiovascular disorders and neurological conditions, highlighting its relevance as a potential therapeutic target and diagnostic biomarker. The protein functions as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as a guanine nucleotide exchange factor (GEF) for RhoA GTPase, and mediates angiotensin-2-induced RhoA activation.