Human Receptor-type tyrosine-protein phosphatase alpha (PTPRA) ELISA Kit

Manufactured by Assay Genie, this Sandwich ELISA Kit is intended for the quantitative measurement of human Receptor-type tyrosine-protein phosphatase alpha (PTPRA) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay targets natural and recombinant human Receptor-type tyrosine-protein phosphatase alpha (also listed under the synonyms Protein-tyrosine phosphatase alpha, PTPA and PTPRL2) and uses an ELISA detection method with reactivity confirmed for human samples.

According to the manufacturer's data, the kit provides a detection range of 0.312-20ng/mL and a sensitivity of 0.084ng/mL, with specificity for natural and recombinant human PTPRA. The target protein, catalogued under UniProt P18433, is a single-pass type I membrane protein and a receptor-type protein tyrosine phosphatase containing an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It has been reported to dephosphorylate and activate Src family tyrosine kinases and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Reported biological processes include axon guidance, insulin receptor signaling pathway, and protein amino acid phosphorylation.

The kit ships with a dismountable ELISA microplate in an 8×12 strip format, lyophilized standard, sample diluent, Assay Diluent A, Assay Diluent B, Detection Reagent A, Detection Reagent B, Wash Buffer, Substrate Solution, Stop Solution and plate sealers, each with individually specified storage conditions. The product is intended for research use only.