Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) ELISA Kit

The PTPN11 gene encodes SHP-2, a non-receptor protein tyrosine phosphatase that plays a central role in signal transduction downstream of receptor tyrosine kinases, cytokine receptors, and integrin signaling cascades. This quantitative immunoassay from Assay Genie is configured to measure human PTPN11 protein levels in tissue homogenates and other sample matrices, supporting research into RAS/MAPK pathway activity, germline mutations associated with Noonan syndrome and LEOPARD syndrome, and somatic PTPN11 alterations implicated in juvenile myelomonocytic leukemia, B-cell acute lymphoblastic leukemia, and solid tumor biology. The kit is supplied in a 96-assay format with a colorimetric readout, intended for research use only in laboratory workflows involving cell lysates, biopsy-derived material, and similar specimen types processed by trained personnel.