Human Protein prune homolog 2 (PRUNE2) ELISA Kit

This Sandwich ELISA kit from Assay Genie is designed for the precise measurement of human Protein prune homolog 2 (PRUNE2) levels in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. It is reactive with human samples. PRUNE2 is described as playing a critical role in cell migration, adhesion, and invasion, with abnormalities linked to various diseases including cancer, neurodevelopmental disorders, and neurodegenerative conditions.

The assay has a detection range of 0.312-20ng/mL and a sensitivity of 0.156ng/mL. Precision is reported with an intra-assay CV of 6.8% and an inter-assay CV of 8.1%. Recovery in serum averages 91% (range 85-97%) and in plasma averages 93% (range 87-99%). The kit is specific for natural and recombinant human Protein prune homolog 2. Synonyms include BNIP2 motif-containing molecule at the C-terminal region 1, BMCC1, BNIPXL, C9orf65, and KIAA0367. The UniProt entry is Q8WUY3, the protein has a molecular weight of 150 kDa, and its subcellular location is the cytoplasm.

According to NCBI, PRUNE2 belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, with members involved in apoptosis, cell transformation, and synaptic function. It has been shown to suppress Ras homolog family member A activity and to act as a tumor suppressor in prostate cancer cells. The kit is intended for research use only.