Human Protein jagged-1 (JAG1) ELISA Kit

From Assay Genie, this Human Protein jagged-1 (JAG1) ELISA Kit is configured as a Sandwich-format immunoassay with colorimetric detection. It is designed for the precise measurement of Jagged-1 in human samples, with reactivity confirmed for serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids, and detects both natural and recombinant human Protein jagged-1.

Reported performance characteristics include a detection range of 0.156-10ng/mL and a sensitivity of 0.082ng/mL. Intra-assay CV is 6.9% and inter-assay CV is 8.8%. Linearity across dilution factors of 1:2 to 1:16 ranged from 103-113% down to 88-97% for serum, 108-117% to 107-117% for EDTA plasma, and 111-121% to 83-93% for heparin plasma. Recovery averaged 89% (range 83-95%) for serum and 91% (range 85-97%) for plasma.

Jagged-1 is a ligand for multiple Notch receptors that mediates Notch signaling, with roles in cell-fate decisions during hematopoiesis, early and late stages of mammalian cardiovascular development, inhibition of myoblast differentiation, and enhancement of fibroblast growth factor-induced angiogenesis. Its dysregulation has been linked to cancer, Alzheimer's disease, and cardiovascular disorders. The protein is also known by the synonyms CD339, Jagged1, and JAGL1; it is a single-pass type I membrane protein with a reported molecular weight of 134kDa (UniProt: P78504). For research use only.