Human Prostaglandin E synthase (PTGES) ELISA Kit

Designed for the reliable measurement of Prostaglandin E synthase (PTGES) in human specimens, this sandwich ELISA kit from Assay Genie supports research requiring accurate quantitation of the target enzyme. The assay is validated for use with serum, plasma, tissue homogenates, cell culture supernatants, and other biological fluids, and uses a colorimetric detection method for straightforward data interpretation.

Reported performance characteristics include a detection range of 0.312-20 ng/mL and a sensitivity of 0.18 ng/mL. Intra-assay CV is stated at 6.3% and inter-assay CV at 9.4%. Specificity is directed toward natural and recombinant human Prostaglandin E synthase. Linearity has been evaluated across serum, EDTA plasma, and heparin plasma at dilutions of 1:2, 1:4, 1:8, and 1:16. Recovery testing shows an average of 100% (range 94-106%) in serum and 102% (range 96-108%) in plasma.

PTGES is a glutathione-dependent, homotrimeric, multi-pass membrane enzyme that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) and belongs to the MAPEG family. Dysregulation of this enzyme has been implicated in cancer, inflammation, and pain, making it a useful biomarker for studies of disease pathogenesis and the development of targeted therapies. The product is intended for research use only.