Human Prostaglandin E synthase 3 (PTGES3) ELISA Kit

From Assay Genie, this Sandwich ELISA kit is designed for the quantitative measurement of human Prostaglandin E synthase 3 (PTGES3), also known by synonyms including cPGES, p23, TEBP, Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, Progesterone receptor complex p23, and Telomerase-binding protein p23. The kit is intended for research use only and detects natural and recombinant human PTGES3 in serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids.

Performance characteristics include a detection range of 0.156–10 ng/mL, a sensitivity of 0.096 ng/mL, an intra-assay CV of 4.2%, and an inter-assay CV of 8.3%. PTGES3 is a cytosolic prostaglandin synthase that catalyses the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2), and it also functions as a molecular chaperone involved in transcriptional regulation and HIF alpha protein hydroxylation. Dysregulation of PTGES3 has been linked to various diseases including cancer, inflammatory disorders, and pain conditions, making the protein a relevant subject within cardiovascular research.

Sample linearity has been validated for serum, EDTA plasma, and heparin plasma at serial dilutions, with documented recovery in serum and plasma samples. The target protein is localised primarily to the cytoplasm, is encoded on chromosome 12q13.3, and corresponds to UniProt entry Q15185.