Human Presenilin 1 (PSEN1) ELISA Kit

Engineered by Assay Genie for quantitative measurement of Presenilin 1 in human-derived samples, this 96 assay kit supports neuroscience and Alzheimer's disease research. Presenilin 1 is the catalytic core of the gamma-secretase complex and is centrally implicated in familial early-onset Alzheimer's disease because missense mutations alter cleavage of the amyloid precursor protein and shift amyloid-beta peptide production. Reliable quantification of PSEN1 protein levels in tissue homogenates and cell lysates supports studies of gamma-secretase activity, biomarker development, and validation of genetic or pharmacologic interventions that target amyloidogenic processing.

The 96 assay format supplies sufficient wells for standard curves and experimental replicates when comparing PSEN1 expression across disease and control cohorts, transfected versus wild-type cell lines, or vehicle versus compound-treated cultures. Each component is supplied in a vial suitable for standard laboratory handling, and the workflow follows conventional ELISA methodology. Researchers studying neurodegeneration, gamma-secretase substrate cleavage, and familial Alzheimer's mechanisms rely on reproducible PSEN1 measurement to connect genotype, protein abundance, and downstream amyloid pathology in human cell and tissue models.