Human PQBP1 ELISA Kit (HUFI07052)

The PQBP1 (Polyglutamine Binding Protein 1) ELISA Kit from Assay Genie enables quantitative detection in research contexts exploring neurodegenerative and neurodevelopmental disease biology. PQBP1 encodes a nuclear protein that recognizes expanded polyglutamine tracts, an interaction central to the molecular pathogenesis of polyglutamine expansion disorders including Huntington's disease and multiple spinocerebellar ataxias. The protein additionally functions within the spliceosome through association with the U5 snRNP 15 kDa component and influences RNA polymerase II-mediated transcription.

Loss-of-function mutations in PQBP1 cause Renpenning syndrome, an X-linked intellectual disability disorder, and altered expression has been reported in studies of stress granules and innate immunity. Researchers apply this in vitro kit to investigate PQBP1 abundance in cultured cell lines, primary neurons, and clinical research specimens drawn from relevant neurological case cohorts.

Each kit is supplied refrigerated on wet ice; consult the enclosed manual for component-specific storage and reconstitution instructions. The product is intended for research use only and is not approved for clinical diagnostic applications.