Human PPP1R15B ELISA Kit (HUFI07084)

Quantitative measurement of Protein Phosphatase 1 Regulatory Subunit 15B (PPP1R15B), also known as CReP (Constitutive Repressor of eIF2α Phosphorylation), in human serum or plasma specimens is enabled by this immunoassay kit from Assay Genie. PPP1R15B is a constitutively expressed regulatory subunit of PP1 that maintains eukaryotic translation initiation factor 2 alpha (eIF2α) in its dephosphorylated state under basal conditions, distinguishing it functionally from its stress-induced paralog PPP1R15A (GADD34). The kit supports research into the integrated stress response, translational control, and conditions where PPP1R15B activity has been implicated, including microcephaly with intellectual disability caused by loss-of-function mutations, certain neurodegenerative and metabolic disease models, and cellular stress pathway studies. Each kit provides reagents for 96 determinations in a microplate format using a chromogenic, absorbance-based readout. The assay is intended for research use only and is compatible with standard laboratory microplate readers. Samples should be aliquoted and handled according to standard immunoassay practice, with refrigerated storage recommended prior to use to preserve analyte integrity.