Human PNKP ELISA Kit (HUFI07158)

PNKP (Polynucleotide Kinase 3'-Phosphatase) is a bifunctional DNA repair enzyme that restores 5'-phosphate and 3'-hydroxyl termini at damaged DNA ends, playing a central role in single- and double-strand break repair. Loss-of-function mutations in the PNKP gene are linked to MCSZ syndrome (microcephaly, seizures, and developmental delay) and Ataxia with Oculomotor Apraxia 4 (AOA4), making the protein a subject of active investigation in neurodegeneration, radiosensitivity, and cancer research.

This enzyme-linked immunosorbent assay from Assay Genie is configured for quantitative measurement of human PNKP, supporting studies in DNA damage response, genotoxicity screening, and biomarker discovery. Supplied as a kit format with 96 assays and intended for research use only, it provides laboratories with a standardized tool for exploring polynucleotide kinase function across disease models and experimental treatment paradigms.