Human PLAUR/uPAR (Plasminogen Activator, Urokinase Receptor) CLIA Kit (HUES00910)

From Assay Genie, this chemiluminescence-based immunoassay kit is designed for the quantitative detection of human PLAUR/uPAR (Plasminogen Activator, Urokinase Receptor) in serum, plasma and other biological fluids. The kit is reactive with human samples and is intended for research use only, supporting a range of research applications including cancer studies.

The analyte, PLAUR (UniProt Q03405), acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation, mediates the proteolysis-independent signal transduction activation effects of uPA, and is subject to negative-feedback regulation by uPA, which cleaves it into an inactive form. PLAUR participates in biological processes including fibrinolysis, cellular protein metabolism, regulation of proteolysis, cell motility, chemotaxis, signal transduction, and blood coagulation. The protein is GPI-anchored and localizes to focal adhesions and the plasma membrane.