Human Platelet glycoprotein Ib alpha chain (GP1BA) ELISA Kit

Assay Genie offers a Sandwich ELISA Kit designed for the precise measurement of human Platelet glycoprotein Ib alpha chain (GP1BA) levels in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. Known synonyms include Antigen CD42b-alpha, CD42b, and GP-Ib alpha. The kit reacts with human samples and is intended for research use only.

GP1BA is a key component of platelets and is essential for platelet adhesion and aggregation during blood clotting processes. It functions as a surface membrane protein that participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Abnormalities in GP1BA expression have been linked to various bleeding disorders and cardiovascular diseases, highlighting its importance as a biomarker for related conditions.

The kit provides a detection range of 15.6-1000pg/mL with a sensitivity of 6.6pg/mL. Intra-assay CV is 3.8% and inter-assay CV is 7.1%. Specificity covers natural and recombinant human Platelet glycoprotein Ib alpha chain. The protein is encoded at chromosomal location 17p13.2, with UniProt accession P07359, and is localised as a single-pass type I membrane protein.