Human Plasminogen activator inhibitor 2 (SERPINB2) ELISA Kit

Assay Genie provides a Sandwich ELISA kit for the quantitative measurement of human Plasminogen activator inhibitor 2 (SERPINB2) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay uses a colorimetric detection method, with a detection range of 0.156-10ng/mL and a sensitivity of 0.086ng/mL. Specificity is stated for natural and recombinant human Plasminogen activator inhibitor 2.

SERPINB2, also known by synonyms including Monocyte Arg-serpin, Placental plasminogen activator inhibitor, Serpin B2, Urokinase inhibitor, PAI-2, PAI2, and PLANH2, is a key regulator of the fibrinolytic system, playing a critical role in controlling blood clot dissolution. It inhibits urokinase-type plasminogen activator, and the monocyte-derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Dysregulation of SERPINB2 has been implicated in various diseases such as cancer, cardiovascular disorders, and inflammatory conditions, highlighting its importance as a potential diagnostic marker and therapeutic target. The corresponding UniProt entry is P05120, with a reported molecular weight of 46,596 Da.

The kit is intended for research use only, within the Immunology research area. The target protein is located in the cytoplasm, is secreted, and is found in the extracellular space. Intra-assay CV, inter-assay CV, linearity, and recovery data are provided with the kit.