Human Phosphotyrosine RET PharmaGenie ELISA Kit (SBRS1947)

This phosphorylation ELISA from Assay Genie enables quantitative measurement of tyrosine-phosphorylated RET receptor in cell lysates and tissue lysates, supporting research into receptor tyrosine kinase signaling, neural crest-derived cancers, and oncogenic RET fusions.

RET phosphorylation events drive downstream MAPK and PI3K/AKT cascades, and quantifying phospho-RET levels helps characterize kinase activation states in response to growth factors such as GDNF. Researchers investigating medullary thyroid carcinoma, multiple endocrine neoplasia type 2, or RET fusion-positive lung cancers can apply this assay to monitor inhibitor efficacy and pathway modulation.

The kit includes pre-coated microplate wells, capture antibodies specific for phosphotyrosine residues, and detection reagents. Store reagents at -20 °C and avoid repeated freeze-thaw cycles to preserve antibody activity. Each kit provides sufficient materials for 96 individual determinations, with a recommended sample volume of 100 uL per well for cell lysate preparations.