Human Pappalysin 2 (PAPPA2) ELISA Kit

The PAPPA2 gene encodes a zinc-binding metalloproteinase that cleaves insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-3 and IGFBP-5, regulating local IGF bioavailability in placental, skeletal, and reproductive tissues. This Assay Genie kit enables quantitative measurement of endogenous Pappalysin 2 protein in experimental samples, supporting investigations into prenatal growth regulation, bone mineralization pathways, and endocrine disorders associated with short stature and postnatal growth phenotypes. The microplate is pre-coated with a human-specific capture antibody, and bound analyte is detected using a biotinylated secondary antibody followed by streptavidin-HRP. Researchers working on pregnancy biomarkers, IGF axis signaling, or pediatric endocrine studies commonly apply this assay to tissue homogenates and cell lysate preparations. For research use only; not intended for diagnostic procedures. Store all unopened reagents refrigerated at 4°C and protect the substrate solution from light to preserve enzymatic activity through the full assay run.