Human P3H4 (Synaptonemal complex protein SC65) ELISA KIT (HUFI05117)

The P3H4 ELISA kit from Assay Genie enables quantitative measurement of human Prolyl 3-Hydroxylase 4, a protein also referred to as Synaptonemal complex protein SC65 and encoded by the LEPREL2 gene. P3H4 belongs to the prolyl 3-hydroxylase family of enzymes that reside in the endoplasmic reticulum, where they catalyze the post-translational hydroxylation of proline residues during collagen biosynthesis. The SC65 isoform was originally identified as a structural constituent of the synaptonemal complex, the protein scaffold that tethers homologous chromosomes together during meiotic recombination.

Beyond its role in meiosis, P3H4 has been investigated in connective tissue and skeletal biology, where altered prolyl hydroxylation patterns have been linked to bone matrix integrity and osteoblast function. Researchers studying collagen folding, ER-resident enzyme activity, and meiotic chromosome structure use this kit to explore the protein's expression profile in human specimens. Each 96 Assays kit is supplied in a vial-based format intended for in vitro research use and should be stored refrigerated to preserve reagent activity across the shelf life of the kit.