Human ORC4L ELISA Kit (HUFI07407)

Quantitative measurement of ORC4L (Origin Recognition Complex subunit 4, sometimes referred to as ORC4) in human research specimens is enabled by this ELISA kit produced by Assay Genie. ORC4L is one of six subunits that assemble into the origin recognition complex, which loads onto chromatin during early G1 phase to license replication origins before S-phase entry. Variants affecting ORC4 have been associated with Meier-Gorlin syndrome, a rare autosomal recessive developmental disorder, while altered ORC4L expression has been reported in tumor cells exhibiting replication stress and re-replication phenotypes.

The 96 Assays configuration includes pre-coated microplate wells, assay buffer, detection antibody, a recombinant standard, substrate reagents, and a wash solution compatible with standard absorbance plate readers. Reconstituted standards and concentrated reagents should be kept refrigerated; for longer term storage, freeze as single-use aliquots, and serum or plasma specimens should be handled similarly to preserve analyte integrity, avoiding repeated freeze-thaw cycles. This product is intended for in vitro research use only, supporting translational work on cell cycle control, DNA damage response, and rare developmental disease models.