Human Optineurin (OPTN) ELISA Kit

OPTN, a ~68 kDa autophagy receptor that links TBK1 kinase signaling to selective clearance of protein aggregates, damaged mitochondria, and intracellular bacteria, can be quantified with the Human Optineurin ELISA kit from Assay Genie. Researchers apply the kit to investigate normal-tension glaucoma, amyotrophic lateral sclerosis (ALS), Paget's disease of bone, and frontotemporal dementia, where OPTN mutations and dysfunction have been widely reported. The pack provides materials for 96 assays, supporting screening of patient cohorts, primary cell culture experiments, and tissue homogenate-based studies of autophagy flux. Because OPTN contains both a ubiquitin-binding UBAN domain and an LC3-interacting region (LIR), measuring its abundance helps characterize activation of selective autophagy pathways under cellular stress, infection, or pharmacological challenge. Intended for research use only; not validated for diagnostic or clinical decision-making. Each kit includes a pre-coated microplate, detection antibody, recombinant standards, and the reagents needed to generate a standard curve for interpolating unknown OPTN concentrations in cleared lysates.