Human Notch Homolog 2 (NOTCH2) ELISA Kit

The Notch Homolog 2 (NOTCH2) transmembrane receptor is a key regulator of cell fate decisions, influencing proliferation, differentiation, and apoptosis across multiple tissue types. This Assay Genie ELISA assay enables quantitative measurement of human NOTCH2 protein in cell lysates and tissue homogenates using a microplate-based protocol. Researchers investigating Alagille syndrome type 2, caused by NOTCH2 mutations that disrupt bile duct and cardiac valve development, B-cell maturation, or solid tumor signaling pathways can apply this kit to in vitro samples. The reagents include a human-specific capture antibody directed against the NOTCH2 extracellular domain, with no significant cross-reactivity with related NOTCH1 or NOTCH3 receptors under standard conditions. Reagents should be refrigerated upon arrival and protected from light; reconstituted standards must be aliquoted and frozen to limit freeze-thaw cycles. For research use only, not for diagnostic or therapeutic procedures.