Human NOTCH-1 PharmaGenie ELISA Kit (SBRS0934)

The NOTCH-1 receptor is a single-pass transmembrane protein that governs cell fate, proliferation, and differentiation through ligand-mediated proteolytic cleavage that releases the NOTCH intracellular domain (NICD). This quantitative plate-based immunoassay from Assay Genie enables researchers to measure circulating and shed NOTCH-1 levels across oncology, hematology, and developmental biology workflows. The kit supports studies of T-cell acute lymphoblastic leukemia (T-ALL), breast and ovarian carcinoma progression, angiogenesis, and stem cell maintenance, where aberrant NOTCH signaling drives disease phenotype. Reconstitute the lyophilized standards in the supplied diluent, run the assay following the enclosed protocol, and capture absorbance on a standard microplate reader. All reagents ship cold-packed; store the lyophilized standard and concentrated detection antibody at -20 degrees C, while diluted working solutions should be refrigerated and used within the recommended assay window.