Human NOD2 (Nucleotide-binding oligomerization domain-containing protein 2) ELISA Kit (HUFI07499)

This Assay Genie ELISA kit enables quantitative measurement of human NOD2, a cytoplasmic pattern recognition receptor central to innate immunity and bacterial sensing. NOD2 detects muramyl dipeptide from peptidoglycan and triggers NF-κB and MAPK signaling cascades, linking it mechanistically to Crohn's disease susceptibility, Blau syndrome, and deregulated autophagy in intestinal epithelial cells.

Researchers apply this in vitro assay to characterize NOD2 expression in inflammatory bowel disease cohorts, screen for variants of interest, and probe downstream cytokine responses. The microplate-based kit is shipped refrigerated; individual components should be stored at the temperatures indicated on the vial labels and protected from light to maintain antibody stability across multiple freeze-thaw cycles.