Human NIPBL ELISA Kit (HUFI07507)

Quantitative measurement of Nipped-B-like (NIPBL) protein in human-derived specimens is enabled by this colorimetric ELISA kit from Assay Genie. NIPBL plays a central role in loading the cohesin complex onto chromatin and in regulating sister chromatid cohesion, and variants in the NIPBL gene are the most common genetic cause of Cornelia de Lange syndrome, a multisystem developmental disorder.

Researchers in chromosome biology, developmental genetics, and chromatin remodeling can apply this assay to investigations of transcriptional regulation, DNA repair processes, and oncology, where altered NIPBL expression has been associated with chromosomal instability in several tumour types. Each kit is supplied in a 96 Assays format and is intended for research use only, with compatibility for plasma and serum specimens. Standard laboratory incubation equipment and a microplate reader capable of colorimetric measurement are required. Store refrigerated until first use.