Human/Mouse/Rat Phospho-SHP2 (Y542) PharmaGenie ELISA Kit (SBRS1966)

Phospho-SHP2 (Y542) ELISA from Assay Genie quantifies tyrosine-phosphorylated SHP2 at residue 542 across human, mouse, and rat samples. SHP2, encoded by PTPN11, is a non-receptor protein tyrosine phosphatase that becomes activated when phosphorylated at Y542, a modification linked to RAS/MAPK pathway signaling. This phosphorylation ELISA kit supports research on cell lysates and tissue lysates, enabling studies of receptor tyrosine kinase downstream signaling, Noonan syndrome models, and cancer cell signaling where SHP2 activation plays a regulatory role. The kit provides reagents in a 96 assays format with an absorbance-based readout that allows comparison of phosphorylated SHP2 levels between treated and untreated samples. Researchers studying growth factor response, cytokine signaling, or developmental biology can monitor SHP2 phosphorylation status in experimental models.