Human/Mouse/Rat Phospho-PTEN (S380) PharmaGenie ELISA Kit (SBRS1938)

A phosphorylation-specific ELISA from Assay Genie, this kit quantifies PTEN phosphorylated at serine 380 (S380) in cell lysates and tissue lysates. PTEN is a lipid phosphatase that functions as a tumor suppressor, and modification of the C-terminal S380 residue is a regulatory event that controls its membrane recruitment, protein stability, and lipid-phosphatase activity within the PI3K/AKT cascade.

Each kit contains a pre-coated microplate, detection antibodies, recombinant phospho-protein standards, and buffer reagents sufficient for 96 individual assays, with a colorimetric endpoint read on a standard plate reader. The capture and detection antibody pair is validated across human, mouse, and rat sample matrices, supporting comparative studies of PTEN regulation in tumor biology, neurodegeneration, and metabolic disease research.

Researchers commonly pair this ELISA with western blot analysis of total PTEN to distinguish changes in overall protein abundance from changes in S380 phosphorylation status under drug treatment, genetic manipulation, or growth-factor stimulation. The assay is supplied ready to use with freshly prepared or frozen lysates, eliminating the need for prior immunoprecipitation, and is intended for research-use-only laboratory applications.