Human MFN1 (Mitofusin 1) ELISA Kit (HUFI07635)

Quantitative measurement of human Mitofusin 1 supports researchers investigating mitochondrial dynamics, fusion-fission balance, and bioenergetic dysfunction in patient and experimental samples. Mitofusin 1 is a dynamin-like GTPase anchored in the outer mitochondrial membrane that drives outer-membrane tethering and fusion, working alongside its paralog MFN2 to maintain mitochondrial network connectivity. Quantifying MFN1 protein abundance aids studies of metabolic disease, neurodegeneration, cardiac stress responses, and hereditary peripheral neuropathies such as Charcot-Marie-Tooth type 2A, where MFN2 mutations are well documented and MFN1 compensation is a frequent research focus.

The Assay Genie kit ships as a complete 96 Assays package for measuring Mitofusin 1 in human specimens. Researchers apply serum or plasma to track systemic changes in MFN1 linked to metabolic syndrome, exercise adaptation, or age-related mitochondrial decline. Standard laboratory workflows pair the assay with western blot confirmation of mitochondrial fractions, qPCR measurement of MFN1 transcripts, and cell culture models of oxidative stress, providing orthogonal validation of protein-level findings.

Storage and handling call for standard cold-chain logistics. Researchers should aliquot reagents to limit repeated freeze-thaw cycles and protect light-sensitive components from degradation. Intended for research use only, the kit enables comparative studies between patient cohorts and matched controls, supporting translational investigation into mitochondrial-targeted therapeutics and biomarker discovery for conditions driven by impaired mitochondrial fusion.