Human Melanocyte protein PMEL (PMEL) ELISA Kit

This Sandwich ELISA Kit from Assay Genie is designed for the precise measurement of human Melanocyte protein PMEL (PMEL) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. It uses a colorimetric detection method and is reactive with human samples, making it suitable for research into melanocyte function, melanin synthesis and pigment production.

The kit offers a detection range of 0.156-10ng/mL with a sensitivity of 0.078ng/mL. Precision figures include an intra-assay CV of 5.3% and an inter-assay CV of 10.2%. Linearity has been validated in serum, EDTA plasma and heparin plasma across dilution ratios from 1:2 to 1:16, and recovery averages 96% in serum (range 90-102%) and 98% in plasma (range 92-104%). Specificity covers natural and recombinant human Melanocyte protein PMEL (UniProt P40967).

PMEL is a melanocyte-specific type I transmembrane glycoprotein that plays a central role in melanosome biogenesis and in the transition of melanosomes from stage I to stage II, contributing to melanin biosynthesis. It serves as a valuable biomarker for studies of skin disorders, melanoma and other pigmentation-related conditions. For research use only.