Human Mcl-1/Bcl2L3 PharmaGenie ELISA Kit (SBRS0862)

A colorimetric immunoassay from Assay Genie's PharmaGenie product line enables quantitative measurement of human myeloid cell leukemia-1 (Mcl-1), an anti-apoptotic member of the Bcl-2 protein family also designated Bcl2L3. Mcl-1 governs mitochondrial outer-membrane permeabilization, and its dysregulation is implicated in B-cell lymphoma, multiple myeloma, autoimmune disease, and tumor chemoresistance, where it is frequently overexpressed.

Validated for human plasma, serum, and cell culture supernatant samples, the kit supports both in vitro cell-based apoptosis studies and translational biomarker profiling from patient-derived fluid samples. The assay uses a microplate format with all reagents included for the standard curve and unknown determinations, and reagents are supplied for research use only.

Typical applications include screening small-molecule Mcl-1 inhibitors, characterizing mitochondrial apoptosis pathways, profiling drug-response signatures in oncology pipelines, and benchmarking Mcl-1 expression across disease models where Bcl-2 family signaling drives experimental outcomes. The Assay Genie brand applies rigorous QC to each production lot, and the kit is intended exclusively for laboratory research applications in cancer biology and apoptosis research.