Human Max dimerization protein 1 (MXD1) ELISA Kit

Designed for the precise quantification of human Max dimerization protein 1 (MXD1) levels, this sandwich ELISA from Assay Genie is intended for research applications. The kit detects natural and recombinant human MXD1 and is suited to studies of transcriptional regulation, with particular relevance to cancer research.

The assay is validated for serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. MXD1 (synonyms: Protein MAD, Max dimerizer 1, MAD) functions as a transcriptional repressor that forms a heterodimer with MAX, recognising the core DNA sequence 5'-CAC[GA]TG-3' and antagonising MYC transcriptional activity by competing for MAX. As a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors, MXD1 mediates cellular proliferation, differentiation and apoptosis, and its dysregulation has been implicated in diseases such as cancer and developmental disorders.

Reported performance characteristics include a detection range of 78-5000 pg/mL and a sensitivity of 45 pg/mL, with intra-assay CV of 6.5% and inter-assay CV of 11.4%. Linearity has been characterised in serum, EDTA plasma and heparin plasma, and recovery has been determined in serum and plasma. For research use only.