Human Major Histocompatibility Complex Class II DR Beta 1 (MHCDRb1) ELISA Kit

MHC Class II DR Beta 1 is a cell-surface glycoprotein central to antigen presentation by professional antigen-presenting cells, and the Assay Genie immunoassay kit enables quantitative measurement of this important immune molecule. Expressed primarily on B lymphocytes, dendritic cells, and macrophages, the DR Beta 1 chain pairs with the DR Alpha chain to form the peptide-binding groove that displays processed exogenous peptides to helper T cells, driving adaptive immune responses.

Researchers apply this colorimetric plate-based assay to investigate HLA-DRB1 expression in autoimmune disease models such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus, where specific DRB1 alleles are well-documented susceptibility factors. Additional applications include transplant immunology studies, vaccine response profiling, and characterization of immune cell populations in inflammation research. Accepts serum specimens alongside plasma aliquots and tissue homogenate preparations, supporting flexibility across in vitro clinical specimen work and in vivo rodent xenograft studies using human hematopoietic cells.

With human-specific reactivity and compatibility with standard laboratory microplate readers, the assay supports translational immunology workflows where peptide-MHC interactions inform therapeutic antibody and small-molecule development. Each kit provides pre-coated plates and reagents sufficient for ninety-six determinations, with bulk packaging that streamlines batched analyses across multiple samples or longitudinal study time points. Reagents are supplied refrigerated for stability and should be stored protected from light until use.